arachidonate (20:4n6) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs3798707

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.090
Position:
10991935
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
7.930
Reference Allele:
C
-log10(P):
-33.754
MAF:
0.431
Beta (Num):
0.016
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.074
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 SMIM13 GCM2

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.1[1], 4[2], 5[3], 6[4], 7[5]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the balance between omega-6 (arachidonate) and omega-3 (DHA) fatty acid synthesis, which are competitively regulated by FADS enzymes.11[1], 12[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of pro-inflammatory omega-6 and anti-inflammatory omega-3 fatty acids.13[1], 11[2] This imbalance is associated with disorders of lipid metabolism, cholelithiasis, and benign colorectal neoplasms, likely through impacts on inflammation and cellular signaling.14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data