arachidonate (20:4n6) to 3-hydroxymyristate

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.309
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-23.120
Reference Allele:
A
-log10(P):
-270.646
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.005
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis1[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

The ratio reflects the rate of arachidonic acid synthesis by FADS enzymes relative to the concentration of 3-hydroxymyristate, a fatty acid associated with metabolic health.1[1], 2[2], 9[3], 10[4], 11[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 influence the levels of arachidonic acid, a key mediator of inflammation.12[1], 3[2], 13[3] Altered arachidonic acid levels are associated with increased risk for inflammatory conditions like cholelithiasis and metabolic disorders such as type 2 diabetes.14[4], 15[5], 16[6], 17[7], 18[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data