arachidonate (20:4n6) to 3-hydroxylaurate

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.305
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-21.609
Reference Allele:
A
-log10(P):
-236.771
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.009
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid metabolism9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio of arachidonate to 3-hydroxylaurate reflects the balance between polyunsaturated fatty acid synthesis by FADS enzymes and fatty acid degradation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Upregulation of FADS1, which converts precursors to arachidonate, is associated with an increased risk and poorer prognosis of colorectal cancer.13[1], 14[2], 15[3], 16[4], 17[5] This suggests that increased FADS1 activity and subsequent higher arachidonate levels may contribute to the development of benign and malignant colon neoplasms.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data