arachidonate (20:4n6) to myristoleate (14:1n5)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.324
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-24.530
Reference Allele:
A
-log10(P):
-304.291
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.009
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain polyunsaturated fatty acid synthesis

Denominator Metabolite Explanation:

De novo lipogenesis

Ratio Explanation:

The ratio of arachidonate to myristoleate reflects the activity of FADS enzymes, which synthesize arachidonate from shorter-chain precursors; a higher ratio indicates greater FADS activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants influence the levels of arachidonate, a key mediator of inflammation.1[1], 4[2], 5[3], 3[4] This altered inflammatory state is linked to benign colorectal neoplasms, a phenotype with Mendelian randomization evidence, and other observed inflammatory and metabolic conditions.1[5], 6[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data