arachidonate (20:4n6) to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.331
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-24.276
Reference Allele:
A
-log10(P):
-298.067
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.016
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid synthesis, eicosanoid precursor4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1], 7[2]

Ratio Explanation:

The ratio of arachidonate (20:4n6) to 5-dodecenoate (12:1n7) reflects the efficiency of polyunsaturated fatty acid synthesis, influenced by FADS1/FADS2 enzyme activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster influence the levels of arachidonic acid.8[1], 9[2] Altered FADS activity and subsequent changes in fatty acid profiles are associated with a range of inflammatory and metabolic disorders, including cholelithiasis and type 2 diabetes.10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data