arachidonate (20:4n6) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.331
Position:
61588305
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-28.065
Reference Allele:
A
-log10(P):
-397.382
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, omega-6 fatty acid biosynthesis.1[1], 3[2], 4[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of arachidonate to 10-nonadecenoate likely reflects FADS1/FADS2 enzyme activity, which is crucial for producing the inflammatory precursor arachidonate.1[1], 3[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 influence arachidonate levels, a key mediator in inflammation and lipid metabolism.9[1] This causally links the gene to inflammatory conditions like phlebitis and metabolic disorders such as pure hypercholesterolemia and cholelithiasis, which are observed phenotypes.10[2], 11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data