arachidonate (20:4n6) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.325
Position:
61588305
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-28.910
Reference Allele:
A
-log10(P):
-421.478
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.011
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1]

Ratio Explanation:

The ratio of arachidonate (20:4n6) to 10-heptadecenoate (17:1n7) reflects the activity of the FADS-mediated polyunsaturated fatty acid synthesis pathway relative to an odd-chain monounsaturated fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 influence the efficiency of arachidonic acid synthesis, an important inflammatory mediator.3[1], 7[2], 8[3], 9[4], 10[5] Altered levels of arachidonic acid and its metabolites (eicosanoids) are associated with inflammatory conditions like asthma, IBD, and metabolic disorders such as type 2 diabetes and dyslipidemia.11[6], 12[7], 8[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data