arachidonate (20:4n6) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.324
Position:
61593005
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-24.697
Reference Allele:
A
-log10(P):
-308.404
MAF:
0.346
Beta (Num):
-0.312
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.012
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
2.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of arachidonate to linolenate reflects the enzymatic efficiency of FADS1 and FADS2 in converting precursor fatty acids to long-chain polyunsaturated fatty acids.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetically determined higher FADS activity leads to an increased arachidonate to linolenate ratio.8[1], 9[2] Elevated arachidonic acid is associated with increased colorectal cancer risk, potentially through pro-inflammatory eicosanoid production and stabilization of β-catenin, promoting tumor growth. 10[3], 11[4], 12[5]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data