arachidonate (20:4n6) to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.598
Position:
61569830
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-24.170
Reference Allele:
C
-log10(P):
-295.511
MAF:
0.339
Beta (Num):
-0.315
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis; Eicosanoid signaling.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2]

Ratio Explanation:

This ratio reflects the conversion of linoleic acid (18:2), contained in the denominator, to arachidonic acid (20:4n6), the numerator, by FADS enzymes.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, impacting the balance of pro-inflammatory arachidonic acid and its precursors.10[1], 7[2] This dysregulation is linked to inflammatory conditions and lipid disorders like pure hypercholesterolaemia, a connection supported by Mendelian Randomization.11[3], 12[4], 7[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data