arachidonate (20:4n6) to 2-hydroxypalmitate

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 2-hydroxypalmitate
Metabolite Accession: GCST90199795
Name: 2-hydroxypalmitate
Hmdb Id: HMDB0031057
Super Pathway: NA
Sub Pathway: NA
Inchikey: JGHSBPIZNUXPLA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.304
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-23.709
Reference Allele:
A
-log10(P):
-284.463
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonate biosynthesis / Eicosanoid synthesis.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Fatty acid alpha-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects FADS enzyme activity; higher values suggest increased arachidonate synthesis from precursors, a key step in producing inflammatory mediators.2[1], 3[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter enzyme activity, impacting the arachidonate to 2-hydroxypalmitate ratio.3[1], 13[2] This dysregulates eicosanoid production, influencing inflammatory pathways and lipid metabolism, which are linked to the development of inflammatory bowel disease, hypercholesterolemia, and benign or malignant neoplasms of the colon.14[3], 15[4], 16[5], 17[6], 18[7], 19[8], 20[9]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data