arachidonate (20:4n6) to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.363
Position:
61543499
SE (Ratio):
0.008
Effect Allele:
C
Z-score (Ratio):
-44.636
Reference Allele:
T
-log10(P):
-1000.199
MAF:
0.370
Beta (Num):
-0.281
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.082
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
2.0
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism.4[1]

Ratio Explanation:

This ratio of arachidonate (product) to its precursor dihomo-linolenate directly reflects the enzymatic activity of FADS1 (delta-5 desaturase).5[1], 6[2], 7[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter its enzymatic activity, changing the arachidonate/dihomo-linolenate ratio.6[1], 7[2] This dysregulation of fatty acid metabolism is strongly associated with altered blood lipid profiles, like pure hypercholesterolaemia, and inflammatory conditions.2[3], 1[4]

Phenotype Driver:

Metabolite-centric[arachidonate/dihomo-linolenate]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data