arachidonate (20:4n6) to (16 or 17)-methylstearate (a19:0 or i19:0)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.328
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-23.639
Reference Allele:
A
-log10(P):
-282.798
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.014
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Branched-chain fatty acid synthesis.6[1]

Ratio Explanation:

The ratio of arachidonate to methylstearate reflects the balance between endogenous synthesis of a pro-inflammatory omega-6 fatty acid and a branched-chain fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 gene variants influence the levels of arachidonic acid, a precursor to inflammatory signaling molecules.7[1], 8[2], 9[3], 10[4] Altered FADS1 activity, reflected in the ratio, is linked to lipoprotein metabolism disorders and cholelithiasis, likely through its established role in modulating hepatic lipid composition and inflammation.11[5], 12[6], 13[7], 14[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data