arachidonate (20:4n6) to n-oleoyltaurine

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.247
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-13.705
Reference Allele:
C
-log10(P):
-96.768
MAF:
0.209
Beta (Num):
-0.008
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.325
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-20.970
Reference Allele:
A
-log10(P):
-223.147
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.010
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, Eicosanoid biosynthesis7[1], 8[2], 9[3], 10[4], 11[5]

Denominator Metabolite Explanation:

N-acyltaurine metabolism12[1], 13[2], 14[3]

Ratio Explanation:

The ratio reflects the relative activity of FAAH, which degrades both N-acyltaurines and the precursor to arachidonate's precursor, and FADS, which synthesizes arachidonate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by the ratio, may increase endocannabinoids, potentially influencing inflammatory pathways associated with cholelithiasis and inflammatory bowel disease.1[1], 15[2], 16[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data