arachidonate (20:4n6) to n-palmitoylglycine

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.344
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-19.941
Reference Allele:
C
-log10(P):
-202.035
MAF:
0.209
Beta (Num):
-0.008
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.315
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
-21.418
Reference Allele:
A
-log10(P):
-232.659
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
9.64e-04
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, Eicosanoid synthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid amide biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the balance between arachidonate synthesis via FADS1/2 and its utilization in fatty acid amide synthesis, a process influenced by FAAH activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH function and altered FADS activity can impact inflammatory and lipid metabolic pathways, potentially contributing to phenotypes like inflammatory bowel disease and dyslipidemia.

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data