arachidonate (20:4n6) to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90199995
Name: sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.502
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-24.053
Reference Allele:
C
-log10(P):
-292.684
MAF:
0.339
Beta (Num):
-0.315
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.186
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Eicosanoid synthesis.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Sphingolipid metabolism.10[1], 11[2], 12[3]

Ratio Explanation:

This ratio reflects the balance between pro-inflammatory arachidonate synthesis, influenced by FADS1/FADS2 activity, and membrane sphingomyelin composition.1[1], 13[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters arachidonate synthesis, a key inflammatory precursor.1[1], 3[2] This altered ratio is associated with increased risk for inflammatory (IBD, asthma), cardiovascular, and metabolic (Type 2 diabetes) diseases, likely by promoting a pro-inflammatory state.1[3], 5[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data