arachidonate (20:4n6) to 1,2-dilinoleoyl-gpc (18:2/18:2)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.610
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-25.053
Reference Allele:
C
-log10(P):
-317.270
MAF:
0.339
Beta (Num):
-0.315
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.295
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of arachidonate to 1,2-dilinoleoyl-GPC reflects the enzymatic efficiency of the FADS-mediated conversion of linoleic acid (18:2) precursors to arachidonate (20:4n6).5[1], 1[2], 2[3], 4[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster influence desaturase activity, altering the arachidonate to linoleic acid-containing lipid ratio.4[1], 6[2] This metabolic shift is causally associated with pure hypercholesterolemia, likely through broad effects on lipid metabolism, including triglyceride and cholesterol levels.7[3], 8[4], 6[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data