arachidonate (20:4n6) to 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.542
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-22.804
Reference Allele:
C
-log10(P):
-263.361
MAF:
0.339
Beta (Num):
-0.315
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Phosphatidylcholine and Phospholipid metabolism10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio of arachidonate to 1-stearoyl-2-linoleoyl-GPC reflects the balance between fatty acid synthesis and its incorporation into phospholipids, influenced by FADS1/2 enzyme activity.14[1], 15[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the activity of desaturase enzymes, affecting the levels of arachidonic acid.1[1], 5[2] This dysregulation of polyunsaturated fatty acid metabolism is associated with an increased risk for disorders of lipoprotein metabolism, pure hypercholesterolemia, and cholelithiasis.16[3], 17[4], 18[5], 19[6], 20[7], 21[8], 22[9], 23[10]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data