arachidonate (20:4n6) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.646
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-29.731
Reference Allele:
C
-log10(P):
-445.595
MAF:
0.339
Beta (Num):
-0.315
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis; Eicosanoid synthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism; Polyunsaturated fatty acid synthesis.5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of arachidonate (product) to a phospholipid containing its precursor (dihomo-linolenoyl) reflects the enzymatic activity of FADS1 (delta-5 desaturase).8[1], 9[2], 10[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter its enzymatic efficiency, impacting the balance of pro-inflammatory (arachidonate-derived) and anti-inflammatory lipids.11[1], 12[2] This dysregulation of fatty acid metabolism is linked to hypercholesterolemia, inflammation, and cardiovascular disease risk.13[3], 14[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data