arachidonate (20:4n6) to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28456

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.464
Position:
61589481
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-23.095
Reference Allele:
A
-log10(P):
-270.067
MAF:
0.310
Beta (Num):
-0.310
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid metabolism.9[1], 10[2], 11[3], 12[4], 13[5]

Ratio Explanation:

The ratio of arachidonate to its precursor dihomo-linolenoylcarnitine reflects the enzymatic activity of FADS1, which is crucial for producing pro-inflammatory arachidonic acid.2[1], 4[2], 14[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by the ratio, is linked to lower arachidonic acid levels, which may modulate inflammatory responses underlying conditions like asthma and inflammatory bowel disease.15[1], 16[2], 17[3], 18[4] Variants in FADS1 are associated with these diseases.19[5], 20[6], 21[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data