arachidonate (20:4n6) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.135
Position:
151879761
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
10.109
Reference Allele:
G
-log10(P):
-53.649
MAF:
0.318
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.313
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-24.221
Reference Allele:
A
-log10(P):
-296.753
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.001
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Eicosanoid signaling5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation8[1], 9[2]

Ratio Explanation:

The ratio reflects fatty acid desaturase (FADS1/FADS2) activity, where higher activity leads to increased arachidonate biosynthesis and potentially decreased levels of shorter fatty acids.10[1], 3[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter enzyme activity, impacting the balance of pro-inflammatory arachidonate-derived eicosanoids and their precursors.12[1], 11[2], 4[3] This dysregulation is linked to inflammatory conditions and diseases like cholelithiasis and benign colon neoplasms, with the ratio itself showing a causal link to colon neoplasms.13[4], 14[5], 15[6]

Phenotype Driver:

Metabolite-centric[arachidonate (20:4n6)]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data