arachidonate (20:4n6) to oleoyl ethanolamide

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.275
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-16.523
Reference Allele:
C
-log10(P):
-139.534
MAF:
0.209
Beta (Num):
-0.008
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.267
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.337
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-23.818
Reference Allele:
A
-log10(P):
-287.053
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.023
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, eicosanoid synthesis.13[1], 14[2], 15[3], 16[4], 17[5], 18[6]

Denominator Metabolite Explanation:

N-acylethanolamine biosynthesis.19[1], 20[2], 21[3], 22[4], 23[5], 24[6], 25[7]

Ratio Explanation:

A higher ratio may reflect decreased FAAH activity, leading to accumulation of the substrate oleoyl ethanolamide relative to arachidonate, a product of other pathways.6[1], 26[2], 27[3], 28[4], 11[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, due to genetic variants, increases oleoyl ethanolamide levels.1[1], 3[2], 4[3], 5[4] Altered oleoylethanolamide signaling impacts energy balance and lipid metabolism, potentially contributing to phenotypes like pure hypercholesterolaemia and cholelithiasis, which are linked to lipid and cholesterol metabolism.29[5], 30[6], 10[7]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data