arachidonate (20:4n6) to linoleate (18:2n6)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.331
Position:
61588305
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-28.993
Reference Allele:
A
-log10(P):
-423.890
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.016
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
2.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio of arachidonate to linoleate reflects the enzymatic efficiency of FADS1/FADS2 in converting omega-6 precursor linoleate to the pro-inflammatory arachidonate.2[1], 3[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzymatic activity, impacting the arachidonate/linoleate ratio.3[1], 4[2] This shift in fatty acid profile is associated with dyslipidemia, including hypercholesterolemia, and inflammatory conditions like cholelithiasis, linking genetic function to disease phenotypes.5[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data