arachidonate (20:4n6) to 3-hydroxybutyrate

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.335
Position:
61592362
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-21.105
Reference Allele:
A
-log10(P):
-225.989
MAF:
0.345
Beta (Num):
-0.311
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.025
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
8.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Ketone body metabolism/synthesis7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the balance between FADS-mediated pro-inflammatory arachidonate synthesis and energy production from ketogenesis, indicating a shift in metabolic state.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants influence arachidonic acid levels, a precursor to pro-inflammatory molecules.10[1], 11[2] This altered inflammatory state is linked to cholelithiasis and benign colon neoplasms.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data