arachidonate (20:4n6) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.146
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
10.147
Reference Allele:
G
-log10(P):
-54.031
MAF:
0.176
Beta (Num):
0.018
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.319
Position:
61588305
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-27.894
Reference Allele:
A
-log10(P):
-392.592
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.005
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

De novo lipogenesis, Monounsaturated fatty acid synthesis

Ratio Explanation:

The ratio reflects the balance between omega-6 polyunsaturated fatty acid synthesis (FADS1/FADS2 activity) and de novo monounsaturated fatty acid synthesis (SCD activity).1[1], 5[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster alters the arachidonate to palmitoleate ratio, impacting pathways of inflammation and lipid metabolism.7[1], 8[2] This contributes to the risk for cholelithiasis and disorders of lipoprotein metabolism, a link supported by Mendelian Randomization.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data