arachidonate (20:4n6) to stearate (18:0)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.304
Position:
61588305
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
-26.340
Reference Allele:
A
-log10(P):
-350.403
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis1[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid elongation7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the efficiency of converting stearate, a saturated fatty acid, into arachidonate, a polyunsaturated fatty acid, a process influenced by FADS enzymes.3[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, affects the arachidonate to stearate ratio, which is associated with dyslipidemia and inflammatory conditions like dermatitis.1[1], 2[2], 11[3] The TMEM258 gene, also implicated, is involved in cellular stress responses.12[4], 13[5]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data