arachidonate (20:4n6) to myristate (14:0)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.322
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-24.892
Reference Allele:
A
-log10(P):
-313.257
MAF:
0.344
Beta (Num):
-0.314
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
10.0
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

The ratio of arachidonate to myristate reflects fatty acid desaturase activity, particularly FADS1, which is involved in the production of arachidonate.1[1], 2[2], 9[3], 10[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity is associated with lower arachidonic acid levels and has been linked to colorectal cancer.4[1], 11[2] Genetic variants in FADS1 are associated with benign colonic neoplasm risk, suggesting the gene's role in tumorigenesis is significant.4[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data