creatinine to etiocholanolone glucuronide

Numerator Metabolite

Structure of creatinine
Metabolite Accession: GCST90200366
Name: creatinine
Hmdb Id: HMDB0000562
Super Pathway: NA
Sub Pathway: NA
Inchikey: DDRJAANPRJIHGJ

Denominator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.473
Position:
99075038
SE (Ratio):
0.052
Effect Allele:
C
Z-score (Ratio):
9.146
Reference Allele:
T
-log10(P):
-44.279
MAF:
0.035
Beta (Num):
0.168
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
-0.304
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Creatine and energy metabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.4[1]

Ratio Explanation:

The ratio reflects muscle turnover and renal function (creatinine) versus steroid hormone breakdown (etiocholanolone glucuronide), but its regulation by ZNF394 is not established.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

ZNF394, a transcription factor, likely influences genes involved in growth (height, BMI) and inflammation (CRP, WBC), with the metabolic ratio being a downstream consequence rather than a direct mediator of these complex phenotypes.

Phenotype Driver:

Gene-centric:ZNF394

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data