creatinine to cortolone glucuronide (1)

Numerator Metabolite

Structure of creatinine
Metabolite Accession: GCST90200366
Name: creatinine
Hmdb Id: HMDB0000562
Super Pathway: NA
Sub Pathway: NA
Inchikey: DDRJAANPRJIHGJ

Denominator Metabolite

Structure of cortolone glucuronide (1)
Metabolite Accession: GCST90200156
Name: cortolone glucuronide (1)
Hmdb Id: HMDB0010320
Super Pathway: NA
Sub Pathway: NA
Inchikey: OKNSFVSKHQJVRN

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.367
Position:
99075038
SE (Ratio):
0.048
Effect Allele:
C
Z-score (Ratio):
7.686
Reference Allele:
T
-log10(P):
-31.816
MAF:
0.035
Beta (Num):
0.168
Novel Locus:
Yes ✔️
SE (Num):
0.036
Beta (Den):
-0.199
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Creatine metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Steroid hormone metabolism, Glucuronidation.6[1], 7[2]

Ratio Explanation:

This ratio compares a product of muscle energy metabolism (creatinine) to a cortisol metabolite, potentially reflecting mitochondrial energy status influencing both pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in ATP5J2 likely alters mitochondrial function, impacting cellular energy (ATP) levels. This can affect body composition (BMI, height) and inflammation (CRP), as mitochondrial health is linked to inflammatory responses and overall metabolic rate.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:ATP5J2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data