creatinine to androsterone glucuronide

Numerator Metabolite

Structure of creatinine
Metabolite Accession: GCST90200366
Name: creatinine
Hmdb Id: HMDB0000562
Super Pathway: NA
Sub Pathway: NA
Inchikey: DDRJAANPRJIHGJ

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs34670419

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.373
Position:
99130834
SE (Ratio):
0.048
Effect Allele:
T
Z-score (Ratio):
7.757
Reference Allele:
G
-log10(P):
-32.375
MAF:
0.033
Beta (Num):
0.178
Novel Locus:
Yes ✔️
SE (Num):
0.037
Beta (Den):
-0.194
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZKSCAN5 FAM200A ZNF655 GS1-259H13.10 ZNF789

LLM Analysis

Numerator Metabolite Explanation:

Creatine metabolism, muscle breakdown, and renal excretion.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen metabolism and glucuronide conjugation for excretion.5[1], 6[2]

Ratio Explanation:

A ratio of creatinine, a marker of muscle mass and renal function, to androsterone glucuronide, an androgen metabolite, possibly co-regulated by ZKSCAN5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

ZKSCAN5, a transcription factor, likely influences metabolic (BMI, CRP, UA) and growth (Height) phenotypes. The ratio of creatinine to androsterone glucuronide serves as a biomarker reflecting the balance between muscle/renal function and androgen metabolism, which is associated with these phenotypes.

Phenotype Driver:

Gene-centric:ZKSCAN5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data