3-hydroxybutyrate to 3-hydroxysebacate

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Associated Genomic Regions

Region: rs10890426

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.309
Position:
47385304
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
13.256
Reference Allele:
G
-log10(P):
-90.676
MAF:
0.125
Beta (Num):
0.062
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.247
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Ketone body metabolism

Denominator Metabolite Explanation:

Fatty acid ω-oxidation

Ratio Explanation:

The ratio may reflect a shift in fatty acid metabolism, where elevated 3-hydroxybutyrate suggests increased ketogenesis and altered CYP4-mediated fatty acid oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No established link between the gene, ratio, and a specific phenotype is available. The ratio suggests a possible alteration in energy and fatty acid metabolism.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data