3-hydroxybutyrate to adrenate (22:4n6)

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.201
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
13.559
Reference Allele:
A
-log10(P):
-94.760
MAF:
0.344
Beta (Num):
0.021
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.181
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ketogenesis, Fatty acid oxidation5[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio reflects competition between fatty acid metabolism pathways; FADS activity influences PUFA synthesis (denominator), while ketone body production (numerator) relies on acetyl-CoA availability.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters PUFA metabolism, impacting circulating lipids and inflammation.8[1], 9[2], 10[3] This dyslipidemia is a known risk factor for associated phenotypes like cholelithiasis (gallstones) and type 2 diabetes.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data