3-hydroxybutyrate to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.161
Position:
61596633
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
11.366
Reference Allele:
C
-log10(P):
-67.254
MAF:
0.346
Beta (Num):
0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.138
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ketogenesis, fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance between fatty acid oxidation for energy (ketogenesis) and polyunsaturated fatty acid synthesis, modulated by FADS enzyme activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster alter desaturase activity, impacting the balance of polyunsaturated fatty acids.8[1], 9[2], 10[3] This dysregulation of lipid metabolism is strongly associated with phenotypes like Type 2 diabetes, hypercholesterolemia, and other lipid metabolism disorders.1[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data