3-hydroxybutyrate to 3-hydroxydodecanedioate*

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of 3-hydroxydodecanedioate*
Metabolite Accession: GCST90199769
Name: 3-hydroxydodecanedioate*
Hmdb Id: HMDB0000413
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYVQCLGZFXHEGL

Associated Genomic Regions

Region: rs10890426

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.194
Position:
47385304
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
8.728
Reference Allele:
G
-log10(P):
-40.495
MAF:
0.125
Beta (Num):
0.062
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.132
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, ketogenesis.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2]

Ratio Explanation:

An elevated ratio may indicate a shift from fatty acid beta-oxidation to omega-oxidation, potentially influenced by CYP4 family enzyme activity on fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No direct ratio-phenotype link is established due to the absence of associated phenotypes. The involved genes, particularly from the CYP4 family, are linked to fatty acid metabolism and could influence this ratio.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data