3-hydroxybutyrate to dodecenedioate (c12:1-dc)*

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of dodecenedioate (c12:1-dc)*
Metabolite Accession: GCST90200159
Name: dodecenedioate (c12:1-dc)*
Hmdb Id: HMDB0000933
Super Pathway: NA
Sub Pathway: NA
Inchikey: MAZWDMBCPDUFDJ

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.197
Position:
47389613
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
9.272
Reference Allele:
C
-log10(P):
-45.446
MAF:
0.128
Beta (Num):
0.058
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.140
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Ketone body metabolism, fatty acid beta-oxidation.11[1], 12[2]

Denominator Metabolite Explanation:

Dicarboxylic fatty acid metabolism, fatty acid omega-oxidation.13[1], 14[2]

Ratio Explanation:

An elevated ratio may suggest increased ketogenesis or reduced dicarboxylic acid metabolism, potentially influenced by the activity of ACOT and CYP enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a direct link cannot be established. However, altered levels of both metabolites have been linked to metabolic disorders.13[1], 15[2], 16[3], 17[4]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data