3-hydroxybutyrate to oleoyl ethanolamide

Numerator Metabolite

Structure of 3-hydroxybutyrate (bhba)
Metabolite Accession: GCST90200367
Name: 3-hydroxybutyrate (bhba)
Hmdb Id: HMDB0000011
Super Pathway: NA
Sub Pathway: NA
Inchikey: WHBMMWSBFZVSSR

Denominator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.317
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-17.186
Reference Allele:
C
-log10(P):
-150.757
MAF:
0.208
Beta (Num):
-0.050
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.267
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
6.0
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Ketogenesis, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Endocannabinoid signaling.7[1], 8[2], 4[3]

Ratio Explanation:

A higher ratio suggests either increased ketone production or decreased degradation of oleoyl ethanolamide by FAAH, reflecting a shift in energy metabolism.5[1], 4[2], 6[3], 9[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH reduces its activity, leading to higher levels of its substrate, oleoyl ethanolamide.10[1], 11[2], 12[3], 13[4], 1[5] There is no established direct link between the gene, the ratio, and a specific phenotype from the provided information.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data