cholesterol to 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*

Numerator Metabolite

Structure of cholesterol
Metabolite Accession: GCST90200368
Name: cholesterol
Hmdb Id: HMDB0000067
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVYWMOMLDIMFJA

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.265
Position:
61557803
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-16.608
Reference Allele:
T
-log10(P):
-140.958
MAF:
0.346
Beta (Num):
-0.045
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.220
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Cholesterol biosynthesis

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis6[1], 7[2]

Ratio Explanation:

The ratio of cholesterol to 1-stearoyl-2-linoleoyl-gpc reflects the balance between cholesterol levels and the synthesis of specific phospholipids containing polyunsaturated fatty acids, influenced by FADS activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 alter the production of polyunsaturated fatty acids, affecting the composition of phospholipids like 1-stearoyl-2-linoleoyl-gpc. This altered lipid metabolism is associated with an increased risk of pure hypercholesterolemia and other related metabolic and inflammatory conditions.5[1], 3[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data