cholesterol to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of cholesterol
Metabolite Accession: GCST90200368
Name: cholesterol
Hmdb Id: HMDB0000067
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVYWMOMLDIMFJA

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.249
Position:
61557803
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-15.268
Reference Allele:
T
-log10(P):
-119.504
MAF:
0.346
Beta (Num):
-0.045
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.203
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Mevalonate pathway, Steroid biosynthesis.9[1], 10[2], 11[3], 12[4], 13[5]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.1[1], 14[2], 15[3], 16[4], 17[5]

Ratio Explanation:

The ratio reflects the balance between sterol synthesis and the synthesis of specific glycerophospholipids, potentially influenced by FADS-mediated polyunsaturated fatty acid availability.18[1], 19[2], 20[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 and FADS2 alters the production of specific polyunsaturated fatty acids, which can impact both cholesterol metabolism and inflammatory pathways, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and inflammatory conditions.21[1], 18[2], 20[3], 22[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data