cholesterol to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of cholesterol
Metabolite Accession: GCST90200368
Name: cholesterol
Hmdb Id: HMDB0000067
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVYWMOMLDIMFJA

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.172
Position:
61557803
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-10.366
Reference Allele:
T
-log10(P):
-56.304
MAF:
0.346
Beta (Num):
-0.045
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.127
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Steroid and cholesterol biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

GPI-anchor biosynthesis and glycerophospholipid metabolism.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

This ratio may reflect the balance of cholesterol and GPI-anchored proteins in membrane rafts, which is influenced by APOE-mediated cholesterol transport.14[1], 15[2], 16[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants, particularly the E4 allele, alter systemic lipid metabolism, increasing the risk for cardiovascular diseases and cholelithiasis, with the cholesterol/GPI ratio potentially reflecting altered cellular lipid composition.1[1], 2[2], 17[3], 18[4]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data