cholesterol to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of cholesterol
Metabolite Accession: GCST90200368
Name: cholesterol
Hmdb Id: HMDB0000067
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVYWMOMLDIMFJA

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.147
Position:
61557803
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-8.702
Reference Allele:
T
-log10(P):
-40.266
MAF:
0.346
Beta (Num):
-0.045
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.102
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis, Mevalonate pathway4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect the balance of lipid components within cell membrane rafts, where FADS1-influenced GPI-anchor fatty acid composition can impact cholesterol homeostasis.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 are linked to altered lipid metabolism and inflammation, influencing phenotypes like hypercholesterolemia, cholelithiasis, and inflammatory bowel disease.12[1], 10[2], 13[3], 14[4], 3[5] The ratio may reflect FADS1-driven changes in membrane lipid composition that underlie these conditions.11[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data