arginine to gamma-glutamylthreonine

Numerator Metabolite

Structure of arginine
Metabolite Accession: GCST90200372
Name: arginine
Hmdb Id: HMDB0000517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ODKSFYDXXFIFQN

Denominator Metabolite

Structure of gamma-glutamylthreonine
Metabolite Accession: GCST90199749
Name: gamma-glutamylthreonine
Hmdb Id: HMDB0029159
Super Pathway: NA
Sub Pathway: NA
Inchikey: GWNXFCYUJXASDX

Associated Genomic Regions

Region: rs60218157

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Clumped rQTL variant

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SNP Summary

Chr:
8
Beta (Ratio):
-0.439
Position:
17424175
SE (Ratio):
0.059
Effect Allele:
C
Z-score (Ratio):
-7.488
Reference Allele:
A
-log10(P):
-30.294
MAF:
0.026
Beta (Num):
-0.221
Novel Locus:
Yes ✔️
SE (Num):
0.049
Beta (Den):
0.218
SE (Den):
0.049
No CNV overlap
rQTL cluster:
86
Reaction Distance:
NA
Closest Genes:
SLC7A2 PDGFRL MTUS1 MTMR7 VPS37A

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, nitric oxide synthesis, protein synthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Gamma-glutamyl cycle, glutathione metabolism.6[1], 7[2]

Ratio Explanation:

This ratio may reflect altered arginine transport by SLC7A2, impacting nitric oxide production, and downstream effects on the gamma-glutamyl cycle.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced arginine transport by SLC7A2 can decrease nitric oxide, a key vasodilator, leading to increased vascular tone and hypertension.3[1], 8[2], 9[3] This aligns with the observed association between SLC7A2 variants and blood pressure.10[4], 11[5]

Phenotype Driver:

Gene-centric:SLC7A2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data