arginine to methionine

Numerator Metabolite

Structure of arginine
Metabolite Accession: GCST90200372
Name: arginine
Hmdb Id: HMDB0000517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ODKSFYDXXFIFQN

Denominator Metabolite

Structure of methionine
Metabolite Accession: GCST90200391
Name: methionine
Hmdb Id: HMDB0000696
Super Pathway: NA
Sub Pathway: NA
Inchikey: FFEARJCKVFRZRR

Associated Genomic Regions

Region: rs74763072

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
8
Beta (Ratio):
-0.443
Position:
17420369
SE (Ratio):
0.056
Effect Allele:
A
Z-score (Ratio):
-7.964
Reference Allele:
G
-log10(P):
-34.028
MAF:
0.025
Beta (Num):
-0.232
Novel Locus:
Yes ✔️
SE (Num):
0.050
Beta (Den):
0.211
SE (Den):
0.050
No CNV overlap
rQTL cluster:
86
Reaction Distance:
2.0
Closest Genes:
SLC7A2 PDGFRL MTUS1 MTMR7 VPS37A

LLM Analysis

Numerator Metabolite Explanation:

Urea cycle, Nitric oxide synthesis4[1], 5[2]

Denominator Metabolite Explanation:

Methionine and Cysteine Metabolism6[1], 7[2]

Ratio Explanation:

The ratio may reflect the balance between arginine transport by SLC7A2 for nitric oxide production and methionine's role as a precursor to homocysteine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC7A2 function could disrupt arginine transport, impacting nitric oxide synthesis and blood pressure regulation, potentially contributing to hypertension.1[1], 8[2] Methionine's link to hypertension is also noted.8[3], 9[4]

Phenotype Driver:

Gene-centric:SLC7A2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data