palmitoleate (16:1n7) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.160
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-9.661
Reference Allele:
G
-log10(P):
-49.172
MAF:
0.176
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism9[1], 10[2], 11[3], 12[4], 13[5]

Ratio Explanation:

The ratio of palmitoleate to DHA reflects the balance between endogenous monounsaturated fatty acid synthesis by SCD and polyunsaturated omega-3 fatty acid metabolism.1[1], 11[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Increased SCD gene activity elevates palmitoleate synthesis.1[1], 5[2] A higher palmitoleate to DHA ratio is associated with an increased risk for cardiovascular diseases like coronary atherosclerosis and myocardial infarction, as well as hypercholesterolemia.14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data