palmitoleate (16:1n7) to stearate (18:0)

Numerator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.225
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-16.977
Reference Allele:
G
-log10(P):
-147.167
MAF:
0.176
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and desaturation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and elongation.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects the activity of Stearoyl-CoA Desaturase (SCD), which converts precursors like stearate's relative, palmitate, into palmitoleate, indicating desaturation efficiency.1[1], 8[2], 9[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Increased SCD activity, indicated by a higher palmitoleate to stearate ratio, is linked to hypercholesterolemia and atherosclerosis.1[1], 9[2], 10[3] Alterations in SCD-mediated fatty acid composition can influence membrane fluidity and signaling, contributing to cardiovascular disease phenotypes.1[4], 9[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data