palmitoleate (16:1n7) to palmitate (16:0)

Numerator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.174
Position:
102075479
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
-19.741
Reference Allele:
G
-log10(P):
-198.055
MAF:
0.176
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.1[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio of palmitoleate to palmitate reflects the activity of Stearoyl-CoA desaturase (SCD), a critical enzyme in the conversion of saturated to monounsaturated fats.8[1], 9[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Increased SCD activity, reflected by a higher palmitoleate-to-palmitate ratio, is linked to coronary atherosclerosis and ischemic heart disease.10[1] This may be due to downstream effects on lipid metabolism, contributing to plaque formation and related cardiovascular phenotypes.11[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data