palmitoleate (16:1n7) to nonadecanoate (19:0)

Numerator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.176
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.891
Reference Allele:
G
-log10(P):
-61.931
MAF:
0.176
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.048
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of palmitoleate to nonadecanoate may reflect SCD enzyme activity, a key regulator of the balance between saturated and monounsaturated fatty acids.1[1], 2[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD gene activity influences the balance of fatty acids.1[1], 2[2] Altered levels of these fatty acids are associated with atherosclerosis, hypercholesterolemia, and cholelithiasis.10[3], 11[4], 12[5], 13[6], 14[7] SCD dysfunction is also linked to blood cell abnormalities, potentially explaining the association with platelet count.15[8], 16[9]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data