palmitoleate (16:1n7) to pentadecanoate (15:0)

Numerator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.170
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-13.624
Reference Allele:
G
-log10(P):
-95.652
MAF:
0.176
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.042
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

De novo lipogenesis, fatty acid biosynthesis.3[1], 2[2]

Denominator Metabolite Explanation:

Exogenous intake (dairy), fatty acid beta-oxidation.4[1], 5[2]

Ratio Explanation:

This ratio reflects endogenous de novo lipogenesis (palmitoleate), catalyzed by SCD, relative to the intake and metabolism of exogenous dairy-fat derived pentadecanoate.2[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SCD influences its activity, altering the palmitoleate/pentadecanoate ratio.6[1], 7[2] Elevated SCD activity is associated with dyslipidemia and an increased risk of coronary atherosclerosis and myocardial infarction, consistent with the observed phenotypes.8[3], 7[4], 9[5]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data