stearate (18:0) to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.288
Position:
102075479
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
12.098
Reference Allele:
G
-log10(P):
-75.906
MAF:
0.176
Beta (Num):
0.097
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.191
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Dicarboxylic acid omega-oxidation.5[1]

Ratio Explanation:

A higher ratio of stearate to decadienedioic acid suggests altered fatty acid metabolism, potentially reflecting decreased SCD activity or impaired beta/omega-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SCD activity, suggested by the elevated stearate/decadienedioic acid ratio, affects fatty acid composition, a known contributor to the pathogenesis of associated phenotypes like coronary atherosclerosis and hypercholesterolemia.1[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data