myristate (14:0) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.180
Position:
102075479
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
17.615
Reference Allele:
G
-log10(P):
-158.237
MAF:
0.176
Beta (Num):
0.052
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, desaturation.6[1], 7[2]

Ratio Explanation:

This ratio reflects desaturase activity; a higher ratio of myristate (14:0) to palmitoleate (16:1n7) suggests lower SCD activity, leading to more saturated fatty acids.8[1], 9[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SCD activity, indicated by an increased myristate/palmitoleate ratio, is linked to altered lipid profiles (dyslipidemia). This metabolic disruption is a known risk factor for cardiovascular diseases, including coronary atherosclerosis and myocardial infarction, which are observed as associated phenotypes.1[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data