glutamine to threonine

Numerator Metabolite

Structure of glutamine
Metabolite Accession: GCST90200419
Name: glutamine
Hmdb Id: HMDB0000641
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZDXPYRJPNDTMRX

Denominator Metabolite

Structure of threonine
Metabolite Accession: GCST90200432
Name: threonine
Hmdb Id: HMDB0000167
Super Pathway: NA
Sub Pathway: NA
Inchikey: AYFVYJQAPQTCCC

Associated Genomic Regions

Region: rs2657879

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.349
Position:
56865338
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-17.220
Reference Allele:
A
-log10(P):
-151.331
MAF:
0.195
Beta (Num):
-0.289
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.060
SE (Den):
0.019
No CNV overlap
rQTL cluster:
51
Reaction Distance:
2.0
Closest Genes:
GLS2 SPRYD4 MIP TIMELESS RBMS2

LLM Analysis

Numerator Metabolite Explanation:

Glutaminolysis, glutamate metabolism, nitrogen metabolism, protein synthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Aspartate family pathway, serine and glycine metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between glutamine catabolism by GLS2 and threonine availability, with GLS2 variants potentially altering glutamine levels and thus the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced GLS2 activity may alter glutamine metabolism, affecting hepatic ammonia detoxification and urea synthesis (BUN), and influencing inflammation (CRP), and liver function (Albumin, TBil).9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:GLS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data