glutamine to asparagine

Numerator Metabolite

Structure of glutamine
Metabolite Accession: GCST90200419
Name: glutamine
Hmdb Id: HMDB0000641
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZDXPYRJPNDTMRX

Denominator Metabolite

Structure of asparagine
Metabolite Accession: GCST90200452
Name: asparagine
Hmdb Id: HMDB0000168
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCXYFEDJOCDNAF

Associated Genomic Regions

Region: rs2933243

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.320
Position:
56860577
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-16.292
Reference Allele:
G
-log10(P):
-135.730
MAF:
0.194
Beta (Num):
-0.288
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
51
Reaction Distance:
1.0
Closest Genes:
MIP SPRYD4 GLS2 TIMELESS RBMS2

LLM Analysis

Numerator Metabolite Explanation:

Glutaminolysis, amino acid metabolism, TCA cycle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Amino acid metabolism, urea cycle.7[1], 8[2], 9[3]

Ratio Explanation:

GLS2-mediated glutamine catabolism decreases glutamine, a substrate for asparagine synthesis, thus altering the glutamine to asparagine ratio.1[1], 7[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered GLS2 activity impacts glutamine catabolism, which can influence ammonia production and the urea cycle, reflected by changes in Blood Urea Nitrogen (BUN), a key phenotype. The negative correlation between glutamine flux and urea synthesis supports this link.10[1], 11[2]

Phenotype Driver:

Gene-centric:GLS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data